Vanillyl butyl ether (Shanghai Cosroma supply 98% Vanillyl butyl ether) is an excellent warming agent, but what is its warming mechanism? This article is a detailed analysis of this from a biological point of view.
The vanillyl group of vanillyl butyl ether (Shanghai Cosroma supply 98% vanillyl butyl ether) is a functional group that plays a key role in inducing warming sensation through the nervous system. Sensory neurons are activated by the binding of vanillyl groups to their receptors, known as vanilloid receptor-1 (VR-1). It is a non-selective cation channel that naturally responds to noxious stimuli such as high temperatures or acidic pH. Upon ligand/receptor binding, the channel opens and causes major calcium ions to flow in through the channel pores. This effect, in turn, causes the membrane to depolarize and, once the threshold is reached, an action potential is generated. The action potential then propagates the axon to the synapse for a long time.
Activated sensory neurons release glutamate, ATP and various neuropeptides as synaptic neurotransmitters. These neurotransmitters eventually reach the central nervous system and emit a series of warmth, which can also be triggered by temperatures of ≥43°C. In neurotransmitters, calcitonin gene-related peptide (CGRP) is one of the known neuropeptides released upon activation, which acts on vascular endothelial cells to trigger vasodilation, thus increasing blood circulation.
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Post time: Feb-02-2019