Glutathione, also known as GSH, belonging to the Tripeptide), composed of glutamic acid, cysteine and glycine, of which The first peptide bond differs from the ordinary peptide bond by the Υ-carboxyl group of glutamic acid and the amino group of cysteine. The cysteine thiol group in the molecule is the main functional group of the compound. As an antioxidant in animal cells, it exists inside water-filled cells and protects DNA from oxidation. Glutathione exists in the human body in both reduc...
Glutathione, also known as GSH, belonging to the Tripeptide), composed of glutamic acid, cysteine and glycine, of which The first peptide bond differs from the ordinary peptide bond by the Υ-carboxyl group of glutamic acid and the amino group of cysteine. The cysteine thiol group in the molecule is the main functional group of the compound. As an antioxidant in animal cells, it exists inside water-filled cells and protects DNA from oxidation. Glutathione exists in the human body in both reduced (G-SH) and oxidized (G-S-S-G) forms, and most of the reduced Glutathione is under physiological conditions.
Glutathione plays an important role in the biochemical defense system in the human body. Its main physiological function is to scavenge free radicals in the human body. It is an important antioxidant in the body and protects many thiol groups in proteins and enzymes. . The structure of L-Glutathione Reduced contains a reactive sulfhydryl-SH, which is easily oxidatively dehydrogenated. This specific structure makes it the main free radical scavenger in the body. For example, when a small amount of H2O2 is formed in the cell, L-Glutathione Reduced reduces H2O2 to H2O under the action of Glutathione peroxidase, which itself is oxidized to GSSG, which is present in the liver and red blood cells. Under the action of Glutathione reductase, H is reduced to L-Glutathione Reduced, so that the free radical scavenging reaction in the body can be continued, and the hemoglobin is protected from oxidation by oxidation, free radicals, etc. Continue to function normally to transport oxygen. The content of Glutathione in human red blood cells is very large, which is important for protecting the sulfhydryl groups of proteins on the red blood cell membrane and preventing hemolysis.
L-Glutathione Reduced is a prosthetic group of glyceraldehyde phosphate dehydrogenase, and is a coenzyme of glyoxalase and triose dehydrogenase. It participates in the tricarboxylic acid cycle and glucose metabolism in the body and activates various enzymes. Such as thiol (-SH) enzyme, etc., thereby promoting the metabolism of sugar, fat and protein, and can affect the metabolism of cells; it can be converted into easily metabolized acid substances by the combination of thiol and free radicals in the body to accelerate freedom. Excretion of the base helps to reduce the side effects of chemotherapy and radiotherapy, and has no obvious effect on the efficacy of chemotherapy and radiotherapy. For example, the main mechanism for protecting renal tubules from cisplatin is the need for detoxification of Glutathione in renal tubular cells. The r-glutamyltranspeptidase, which is absent from cancer cells, protects normal tissues but organs without affecting the cytotoxic effect of L-Glutathione Reduced. The therapeutic effect on radiation enteritis is obvious; for patients with systemic or local hypoxemia caused by anemia, poisoning or tissue inflammation, tissue damage can be alleviated and repair can be promoted.
L-Glutathione Reduced can also improve human immunity, protect the -SH group in the enzyme molecule, facilitate the enzyme activity, and restore the active function of the -SH group in the destroyed enzyme molecule, so that the enzyme can be reactivated. Restore activity. L-Glutathione Reduced maintains health and anti-aging, and is more effective than young people in slowing cells of the elderly. L-Glutathione Reduced also inhibits the fatty liver produced by ethanol against the liver.
L-Glutathione Reduced has a strong protective effect against symptoms such as leukopenia caused by radiation and radioactive drugs. L-Glutathione Reduced can combine with toxic compounds, heavy metal ions or carcinogens entering the human body, and promote its excretion, neutralize and detoxify; easy to interact with certain drugs (such as paracetamol), toxins ( Such as free radicals, iodoacetic acid, mustard gas, lead, mercury, arsenic and other heavy metals) combined with integrated detoxification.
Applications of L-Glutathione Reduced:
- In the pharmaceutical industry
At present, L-Glutathione Reduced drugs have been artificially developed and widely used in clinical practice. In addition to using sulfhydryl groups to chelate heavy metals, fluorides, mustard gas and other toxins, they are also used in hepatitis and hemolytic diseases. Keratitis, cataracts, and retinal diseases, as drugs for treatment or adjuvant therapy. In recent years, Western scientists, especially Japanese scholars, have found that Glutathione has the function of inhibiting HIV.
- In the cosmetics industry
Recent studies have also shown that L-Glutathione Reduced can correct the imbalance of acetylcholine and cholinesterase, play an anti-allergic effect, prevent skin aging and pigmentation, reduce melanin formation, and improve skin antioxidant capacity. Gives the skin a shine. Since L-Glutathione Reduced has whitening effect, since 2010, many businesses have added L-Glutathione Reduced to skin care products or cleansing products, or made it a nutritional supplement.
- In the health care industry
L-Glutathione Reduced also protects the liver from synthesis, detoxification, inactivation of hormones, etc., and promotes bile acid metabolism, which is beneficial to the digestive tract to absorb fat and fat-soluble vitamins (A, D, E, K). Vitamin C can reversibly hydrogenate or dehydrogenate. The active group of many enzymes is sulfhydryl (-SH). Vitamin C can maintain -SH in a reduced state while maintaining enzyme activity; vitamin C can transform oxidized Glutathione It is a reduced Glutathione (L-Glutathione Reduced), which reduces the hydrogen peroxide (H2O2) produced by the body’s metabolism; vitamin C also protects vitamins A, E and certain B vitamins from oxidation. Therefore, when Glutathione is used, it can be used in combination with vitamin C to improve liver and liver protection.
- In the food industry
1. L-Glutathione Reduced is added to the noodle product, which can reduce the time of making the bread to 1/2 or 1/3 of the original bread, and strengthen the food nutrition and other functions. .
2. L-Glutathione Reduced is added to yogurt and infant foods to act as a stabilizer.
3. L-Glutathione Reduced can prevent the taste nucleotides in the taste nucleotides (inosinic acid, guanylic acid) foods (fish cakes, sausages, soy sauce, etc.) from decomposing and losing the fresh taste. Prevent the color from deepening.
4. L-Glutathione Reduced has the function of eliminating the formation of oxidized lipids, and has anti-oxidation effect, and is added to foods such as meat products and cheese to have an effect of enhancing flavor.